mild to moderate Graves ophthalmopathy
Conditions
Interventions
A:Selenium treatment
Sponsors
1st affiliated hospital of China medical university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with a history of Graves' hyperthyroidism, who have been rendered euthyroid for at least 2 months by antithyroid drugs, or surgery. If 131-Iodine is used, at least 6 months should lapse before recruitment. Euthyroidism is defined as normal serum free T4, and normal free T3 or total T3 levels, in the absence of an elevated serum TSH concentration. All patients should remain euthyroid during the duration of the 6 study, and no thyroid surgery or treatment with 131I should be given. Patients should not be treated with systemic steroids, orbital radiotherapy or any other specific medication or surgical treatment for their eye disease during the study, unless the deteriorates; 2. Patients should at least have one sign of Graves' ophthalmopathy, with a disease duration of less than 18 months (as recorded by the patient); 3. The ophthalmopathy has not been treated in the past by any means, except for local measures (e.g. eye drops); 4. Age 18-65 years.
Exclusion criteria
Exclusion criteria: 1. Soft tissue swelling NO SPECS class 2.c (e.g. severe chemosis, severe eye lid swelling) according to the Color Atlas; 2. Proptosis of more than 22 mm; 3. Diplopia in primary or reading position, and/or ocular torticollis; 4. Mono-ocular duction in any direction of less than 20 degrees; 5. Signs or symptoms of optic nerve involvement; 6. Pregnant or planning pregnancy, or in lactating; 7. History of alcoholism or drug abuse; 8. Have severe concomitant diseases, such as liver, renal insufficiency, diabetes mellitus, other systemic autoimmune diseases; 9. Can not always carry out the test; not been informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| thyrotropin;Free thyroxine;serum Selenium;Thyrotropin receptor antibody;Glutathione peroxidase;vision;exophthalmos;intraocular tension;Eyelid measurement;Soft tissue infiltration; | — |
Countries
China
Contacts
Public ContactYushu Li
Outcome results
None listed