total knee arthroplasty
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Written informed consent was obtained from all patients; 2. Patients undergone primary unilateral total knee arthroplasty for OA or RA.
Exclusion criteria
Exclusion criteria: 1. allergy or intolerance to one of the study drugs; 2; epilepsy; 3. language difficulty, mental illness, dementia; 4. preexisting neuropathy on the operative limb; 5. alcoholism, chronic opioid use (defined as daily or almost daily use of opioids for longer than 3 months); 6. body mass index greater than 35 or smaller than 20; 7. aged younger than 18 or older than 80 years; 8. American Society of Anesthesiologists (ASA) class 4 or 5.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain scores at postoperative hours 2, 4, 8, 12, 24, 48, 72 in rest and motion;Quadriceps strength at postoperative hours 2, 4, 8, 12, 24, 48, 72;total opioid consumption;sleep interruptions causing by the pain after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Complications;postoperative hospitalization days;range of motion in knee joint postoperative; | — |
Countries
China