Glaucoma
Conditions
Interventions
Intervention vs control:Using additional eye drops and/or laser procedure to achieve 20% intraocular pressure (IOP) lowering from baseline. Drug: prostaglandin analogue, brimonidine and carbonic anhyd
Sponsors
Hong Kong Eye Hospital, The Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. To be aged older than 18 years; 2. Best corrected visual acuity more than 20/40; 3. POAG patients diagnosed within 12 months without prior history of glaucoma surgical/laser procedure and receiving not more than one topical IOP lowering medication.
Exclusion criteria
Exclusion criteria: IOP higher than 30mmHg measured at any time points during the screening visit; high myopia (spherical error less than -6.0D); moderate and advanced VF loss (VF MD less than -6dB in the worse eye) or defects close to fixation (any one of the paracentral points with sensitivity less than 10dB); inability to perform reliable VF; suboptimal quality of SDOCT images (see SDOCT imaging); previous intraocular surgery other than uncomplicated cataract extraction; and diabetic retinopathy/maculopathy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of eyes with VF progression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of eyes with RNFL progression;Rate of change visual field index;Rate of change of LC deformation before and after IOP reduction;Risk factors of LC deformation; | — |
Countries
China
Contacts
Public ContactProf. Leung Christopher Kai Shun
Hong Kong Eye Hospital, The Chinese University of Hong Kong
Outcome results
None listed