Adult Heart Valve Disease
Conditions
Interventions
RIPC:Limb Remote Ischemic Preconditioning and sevoflurane
Placebo:sevoflurane
Sponsors
Guangzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: inclusion criteria were being scheduled for elective heart valve repair surgery and age of 18–70yrs.
Exclusion criteria
Exclusion criteria: The exclusion criteria applied were as follows: persistent tobacco abuse, body mass index greater than 35 kg/m2, history of treatment with immunodepressant drugs in the 6 weeks before surgery, emergency surgery, cardiac failure (New York Heart Association class greater than II), peripheral vascular disease, clinically relevant obstructive or restrictive lung diseases (vital capacity or forced expiratory volume in 1 s lower than 50% of the predicted values), pulmonary hypertension (mean pulmonary arterial pressure greater than 60 mmHg), or preexisting coagulation disorders.Patients with evidence of pulmonary or systemic infections (clinically defined or increased C-reactive protein serum concentrations greater than 5 mg/l, leukocytosis greater than 10.0 gigaparticles/liter, or body temperature higher than 37 degree) were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a/A ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| A-aDO 2;pulmonary dynamic and static compliance;respiratory index;TNF-alpha;duration of mechanical ventilation;length of hospital and intensive care unit stay;oxygenation index; | — |
Countries
China
Contacts
Public ContactShe Shouzhang
Outcome results
None listed