Osteoarthritis
Conditions
Interventions
Group 1:celecoxib and exercise therapy
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged between 40 years and 70 years; 2. Mild or moderate knee osteoarthritis; 3. No bone or cartilage metabolic disease; 4. No history of knee trauma, meniscus and ligament damage; 5. No cardiovascular disease and diabetes; 6. Participants who had written informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Taking other anti-inflammatory drugs before the beginning of the study; 2. Allergic to sulfa drugs; 3. Participants with serious cardiac insufficiency or respiratory insufficiency; 4. Participants with liver and renal insufficiency; 5. Women during their pregnant and lactation period; 6. Inducing asthma, urticaria or other allergic reaction after using aspirin or non-steroidal anti-inflammatory drugs; 7. Participants with active ulcer or hemorrhage of gastrointestinal tract; 8. Participants with severe cognitive impairment, sensory aphasia and mental disorder who couldn't understand basic instructions; 9. Participants with other diseases seriously affected lower limb sensory or motor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Western Ontario and McMaster Universities Arthritis Index (WOMAC);Visual Analogue Scale (VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Six minute walking test;Timed Up and Go;Knee injury and Osteoarthritis Outcome Score (KOOS); | — |
Countries
China
Contacts
Public ContactChengqi He
West China Hospital, Sichuan University
Outcome results
None listed