Infertility
Conditions
Interventions
Fresh embryo transfer group:2 fresh clavage stage embryo transfer
Frozen embryo transfer group:freeze all embryo and 2 thawed clavage stage embryo transfer
Sponsors
Center for Reproductive Medicine, Shandong University
Eligibility
Sex/Gender
Female
Age
20 Years to 34 Years
Inclusion criteria
Inclusion criteria: 1. Women who have a history of infertility longer than at lest one year; 2. Women to be aged older than 20 and younger than 35 years old; 3. Women who have normal menstrual cycle defined as spontaneous cycle length longer than 21 days and shorter than 35 days; 4. Women undergoing their first cycle of IVF or ICSI due to tubal factor or (and) male factor: a. Tubal factors: unilateral or bilateral tubal obstruction, adhesion, unilateral or bilateral salpingectomy or tubal ligation; b. Male factors: oligoasthenozoospermia or obstructive azoospermia; 5. Women whose retrieved oocytes number of 5 or more.
Exclusion criteria
Exclusion criteria: 1. Women who have undergone unilateral oophorectomy; 2. Women who had ever been diagnosed with PCOS; 3. Women who have previously been diagnosed with a uterine abnormality such as a malformed uterus (uterus unicornis, septate uterus, duplex uterus or uterus bicomis), adenomyosis, submucous myoma, intrauterine adhesion, or scarred uterus; 4. Women or their partners with an abnormal chromosome karyotype not including chromosome polymorphisms, which mainly refer to the variants in the chromosomal heterochromatin region; 5. Women who have experienced recurrent spontaneous abortions (including biochemical pregnancy abortion), defined as 2 or more previous pregnancy losses; 6. Women with chronic medical conditions that have confirmed effects on pregnancy, such as hypertension, symptomatic heart diseases, diabetes, undiagnosed liver disease or dysfunction (based on serum liver enzyme test results), renal disease or abnormal renal function, severe anemia, history of deep venous thrombosis, pulmonary embolus or cerebrovascular accident, history of cancer; 7. Women who has high risk of ovarian hyperstimulation syndrome (OHSS) during controlled ovarian hyperstimulation; 8. Women who are unable to comply with the study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate; | — |
Countries
China
Contacts
Public ContactZi-Jiang Chen
Center for Reproductive Medicine, Shandong University
Outcome results
None listed