Sepsis or septic shock
Conditions
Interventions
Experimental:polymyxin B hemoperfusion added to conventionalmed
Control:conventionalmedical therapy
Sponsors
Department of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Sepsis or septic shockdue to abdominal cavity infection: (1) After emergency abdominal surgery; (2) SOFA score=10, and Cardiovascular SOFA score more than 2; 2. Aged between 18 to 75 years; 3. Weight more than 40kg; 4. Informed consentwas obtained frompatient or the patient's relative or surrogate.
Exclusion criteria
Exclusion criteria: 1Traumatosepsis 2Patients with the intracranial hemorrhage or uncontrollablehemorrhage 3?Chronic organ dysfunction syndrome(Including Chronic Renal Failure) 4?have chosen palliative care and signed Do Not Resuscitate sheet 5?Accompanied by ? degree burns or scald 6?history of sensitivity to polymyxin B or to anticoagulant (heparin) 7?Severe granulocytopenia (leukocyte count of 0.5×109/L) 8?Severe thrombocytopenia (platelet count of 30×109/L) 9?Organ transplantation in the last year 10?Women who are either pregnant or breast feeding. 11?HIV-positive 12?Suspect case of active tuberculosis 13?Use of other investigational drugs at the time of enrolment or within 3 months before study entry 14?Unsuitable patients considered by researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SOFA score at Day 3, 7, 14; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of MVP at Day 3, 7, 14;Total mortality;Change of vasoactive drugs at Day 3, 7, 14;Change of CAI at Day 3, 7, 14;Change of PaO2/FiO2 at Day 3, 7, 14;Ventilator Free Day;AKI Morbidity;Change of inflammatory cytokines (IL-6, TNF-alpha);Change of Endotoxin;Length of ICU stay; | — |
Countries
China
Contacts
Public ContactPing Fu
Outcome results
None listed