Type 2 diabetes mellitus
Conditions
Interventions
experimental group 1 :Oral probiotics
experimental group 2:Oral Vilof water-soluble dietary fiber
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: The first-degree relatives of type 2 diabetes mellitus (contains parents, offspring, brothers and sisters)
Exclusion criteria
Exclusion criteria: 1. Known or suspected to be allergic to intervention products; 2. pregnancy, lactation, planning pregnancy during experiment or women of childbearing age not using proper contraceptive methods(sterilization, IUD, oral contraceptive or barrier contraception); 3. Antibiotics were received within 14 days of screening; 4. Acute coronary events or acute cerebrovascular events occurred within 90 days before random grouping; 5. Liver function lesion (liver function is 3 times higher than normal); 6. Renal function was impaired and defined to calculate the estimated glomerular filtration rate (eGFR) < 60 ml/min / 1.73 m2, according to the MDRM formula (4 variable version); 7. Mental disorders, unwilling or unable to properly understand or comply with the research procedures due to language barriers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oral glucose tolerance test;glycosylated hemoglobin;hepatorenal function;blood lipid;Hypersensitive c-reactive protein;Thyroid function tests;stool routine test;intestinal flora;inflammatory factor; | — |
Countries
China
Contacts
Public ContactDong Youping
General Hospital of Ningxia Medical University
Outcome results
None listed