diarrhea-predominant irritable bowel syndrome
Conditions
Interventions
TO:placebo for 4 weeks
T1:amitriptyline 25mg/qn, p.o, for 4 weeks
T2:amitriptyline 12.5mg/qn, p.o, for 4 weeks
T3:amitriptyline 6.25mg/qn, p.o, for 4 weeks
Sponsors
Guangzhou First Municipal People's Hospital, Guangzhou Nan Sha Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients from the gastroenterology outpatient of Nansha Center Hospital of Guangzhou First Municipal People's Hospital who conform to the Rome IV criteria for irritable bowel syndrome: Subjects must have had recurrent abdominal pain for 3 or more days per month in the nearly three months for > 6 months and the following 2 symptoms or more: (1) Improvement of symptoms after a bowel movement; (2) Abnormal frequency of defecation; (3) Stool changes. 2. Aged 18-65 years; 3. Signed informed consent and agreed to enter the study.
Exclusion criteria
Exclusion criteria: the presence of any organic disease related to endoscopy; prior gastrointestinal surgery4severe cardiachepatic renal respiratory dysfunction; pregnancy or breast feeding;known allergy to amitriptyline7modertate to severe depression or anxiety
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IBS-SSS;The Adequate Relief question;Inflammatory factors;Hamilton Depression Rating Scale;Hamilton Anxiety Rating Scale;Pittsburgh Sleep Quality Index;Side effect;CYP2D6 genotypes;serum levels of amitriptyline (At) and nortriptyline (Nt); | — |
Countries
China
Contacts
Public ContactLin Jia
Guangzhou First Municipal People's Hospital, Guangzhou Nan Sha Central Hospital
Outcome results
None listed