eldly patients
Conditions
Interventions
one:2.0ng/ml remifentanil, 1.0ug/ml propofol
two:2.0ng/ml remifentanil, 1.5ug/ml propofol
three:2.0ng/ml remifentanil,2.0ug/ml propofol
four:3.0ng/ml remifentanil, 1.0ug/ml propofol
five:3.0ng/ml remifentanil, 1.5ug/ml propofol
six:3.0ng/ml remifentanil, 2.0ug/ml propofol
Sponsors
Anhui provincial hospital
Eligibility
Sex/Gender
All
Age
65 Years to 79 Years
Inclusion criteria
Inclusion criteria: Aged 65-79 years, ASA grade I ~ III patients, scheduled for elective surgery in general anesthesia, and are expected to stay in hospital for observation treatment over 48h; All patients have signed informed consent. All patients are not combined with no serious candic, cerebral and respitory disease, no serious liver and kidney dysfunction, no history of mental illness, with no unconsciousnes.
Exclusion criteria
Exclusion criteria: The body mass index (BMI) 30 kg/m2; the patients with abnormal liver and kidney function (ALT) or (AST) more than 1.5 times the upper limit of the normal value; creatinine greater than 1.5 times the upper normal limit or dialysis treatment within one month before the operation; heart and lung function of severe organic diseases (such as severe heart valvular disease, cardiac ejection fraction <55%, need to install the pacemakers in various kinds of arrhythmia, atrial fibrillation, pulmonary function damage etc.); the hearing impairment; the related drug allergy medication; the 24h before taking diazepam, opioid analgesic substance; the preoperative fasting time have obvious dehydration and electrolyte disorders; Other researchers believe that the situation is not suitable for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time;blood pressure;heart rate;BIS value;Propofol plasma and effect compartment concentration; | — |
Countries
China
Contacts
Public ContactWei Xin
Anhui provincial hospital
Outcome results
None listed