hepatobilliary disease and appendix disease
Conditions
Interventions
R1 group:the effect-site concentration of the remifentanil is 2.5ng/ml
R2 group:the effect-site concentration of the remifentanil is 3.0ng/ml
R3 group:the effect-site concentration of the remifentanil is 3.5ng/ml
R4 group:the effect-site concentration of the remifentanil is 4.0ng/ml
R5 group:the effect-site concentration of the remifentanil is 4.5ng/ml
R6 group:the effect-site concentration of the remifentanil is 5.0ng/ml
R7 group:the effect-site concentration of the remifentanil is 5.5ng/ml
R8 group:the effect-site concentration of the remifentanil is 6.0ng/ml
R9 group:the effect-site concentration of the remifentanil is 6.5ng/ml
R10 group:the effect-site concentration of the remifentanil is 7.0ng/ml
Sponsors
Xuanwu Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
19 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing scheduled surgery in Xuanwu Hospital of Capital Medical University; 2. All genders; 3. Aged 18-65 years old; 4. ASA physical status 1 or 2; 5. Surgery including laparoscopic cholecystectomy, laparoscopic choledocholithotomy, appendectomy, laparoscopic liver cyst fenestration, hapatic hemangioma resection; 6. Undergoing endotracheal intubation; 7. BMI<30; 8. Mallampati classification 1-2.
Exclusion criteria
Exclusion criteria: 1. The patient's too old or too young; 2. Patient's undergoing emergency surgery; 3. ASA physical status >=III; 4. Any history including psychiatric disease, disease causing chronic pain(for instance, chronic sciatica), endocrine disease (patients suffering from diabetes are excluded no matter how well the blood sugar is controlled), hypertension more than grade 1, central neurological disease, analgesic drug abuse (including NSAIDs), chronic self-immune diseases (prevent the disease from getting worse, however, local immune diseases like the Spring Catarrhal Conjunctivitis are not included); 5. Blood pressure dropped for more than 20% of the basic value; 6. Mallampati classification >=3.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SPI index when entering the OR;heart rate when entering the OR;blood pressure when entering the OR;bispectrl index when entering the OR;heart rate when BIS maintains at 50±5;blood pressure when BIS maintains at 50±5;SPI index when BIS maintains at 50±5;BIS value when BIS maintains at 50±5;heart rate when the neuromuscular block reaches the maximum effect;blood pressure when the neuromuscular block reaches the maximum effect;SPI index when the neuromuscular block reaches the maximum effect;BIS value when the neuromuscular block reaches the maximum effect;heart rate when the remifentanil reaches the effect site concentration;blood pressure when the remifentanil reaches the effect site concentration;SPI index when the remifentanil reaches the effect site concentration;BIS value when the remifentanil reaches the effect site concentration;the maximum heart rate after intubation;the maximum blood pressure after intubation;the maximum SPI index after intubation;the maximum BIS value after intubation;heart rate after incision;blood pressure after inscision;SPI index after incision;BIS value after insicion;heart rate after the pneumoperitoneum is built;blood pressure after the pneumoperitoneum is built;SPI index after the pneumoperitoneum is built;BIS value after the pneumoperitoneum is built;heart rate after the Trocar is inserted;blood pressure after the Trocar is inserted;SPI index after the Trocar is inserted;BIS value after the Trocar is inserted;heart rate before incision;blood pressure before incision;BIS value before incision;SPI index before the incision;blood pressure before the pneumoperitoneum is built;heart rate before the pneumoperitoneum is built;BIS value before the pneumoperitoneum is built;SPI index before the pneumoperitoneum is built;heart rate before the Trocar is inserted;blood pressure before the Trocar is inserted;BIS value before the Trocar is inserted;SPI index before the Trocar is inserted; | — |
Secondary
| Measure | Time frame |
|---|---|
| the time duration from the anesthesia begining to operation start;the time duration of the intubation;the time duration for the systolic pressure under 80mmHg;the time duration for the systolic pressure over 20% of the basic value;the time duration for the heart rate faster than 20% of the basic value;the time duration for the heart rate lower than 45 beats/min;the time duration of the surgery;Numerical Rating Scale;postoperative pharynaglgia;postoperative trachyphonia; | — |
Countries
China
Contacts
Public ContactWang Tian-long
the Department of Anesthesiology and Operating Theatre, Xuanwu Hospital of Capital Medical University
Outcome results
None listed