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Can serine protease inhibitors (SPI) be protective to Endothelial glycocalyx layer from shedding following lung resection surgery?

Can serine protease inhibitors (SPI) be protective to Endothelial glycocalyx layer from shedding following lung resection surgery?

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOC-17010416
Enrollment
Unknown
Registered
2017-01-13
Start date
2017-01-16
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

the dysfunction of vascular barrier function

Interventions

experiment: Urinary trypsin inhibitor infusing
control group:NA

Sponsors

the anesthesiology department of Beijing Chaoyang Hospital Affiliated to the Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: patients undergoing lobectomy surgery, aged forty to eighty, all genders, operation time three to six hours

Exclusion criteria

Exclusion criteria: severe infection,uncontrolled diabetes mellitus, dysfunction,renal dysfunction,long-term steroids or anticoagulant therapy, severe malnutrition ,etc.

Design outcomes

Primary

MeasureTime frame
C- reaction protein;iL-6;Syndecan-1;—

Secondary

MeasureTime frame
PaO2/FiO2 ratios;hospital mean length of stay;—

Countries

China

Contacts

Public ContactWu,Yan

Beijing Chaoyang Hospital Affiliated to the Capital Medical University

yhanwu@sina.com+86 13651077828

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 27, 2026