Aggressive periodontitis
Conditions
Interventions
Generalized aggressive periodontitis group vs Healthy population :Active periodontal treatment (APT) includes oral hygiene instruction, supragingival scaling, and quardrant-based subgingival scaling a
Sponsors
Peking University School and Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: The diagnostic criteria forgeneralized aggressive periodontitis is according to the classification proposed at the International Workshop for the Classification of Periodontal Diseases and Conditions in 1999. The inclusion criteria of the generalized aggressive periodontitisgroup are: 1. The onset of the periodontal disease occurred under 35 years old; 2. At least 8 teeth with probingdepth (PD)over 5 mm and attachment loss (AL) over 3 mm, three or more of which are not first molars or incisors; 3. Radiographs showed alveolar bone loss; 4. At lease 20 functional teeth remained, at least 1 molar remained in every quadrant. In addition, periodontal healthy subjects are selected from the staffs and students at Peking University School and Hospital of Stomatology; the inclusion criteria are: 1. PD <=3 mm; 2. The percentage of sites with bleeding on probing (BOP) is<10%; 3. No attachment loss (AL); 4. No bone loss visible on radiographs.
Exclusion criteria
Exclusion criteria: 1. Less than 18 years old; 2. Current or previous smoker; 3. The presence of systemic disease or pregnant; 4. History of periodontal therapy or antimicrobial therapy within 6 months, or usage of any medication (including oral contraceptive drugs) within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probing depth;Attachment loss;Bleeding index;White blood cell count;Neutrophile granulocyte percent;Neutrophile granulocyte count;Platelet count;Platelet distribution width;Platelet large cell ratio;Mean platelet volume;CD62P;PAC-1;S100A9;Platelet-leukocyte aggregate;IL-1 beta;IL-6;CRP;TNF-alpha;sCD62P;sCD40L;beta-TG;PF-4;Vov willebrand factor;CD40L;Platelet-neutrophil aggregate;Platelet-monocyte aggregate;Platelet-lymphocyte aggregate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Triglyceride;Total cholesterol;High density lipoprotein;Low density lipoprotein;Fasting glucose; | — |
Countries
China
Contacts
Public ContactMeng Huanxin
Outcome results
None listed