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Remote Ischemic Preconditioning mediate MicroRNA to Protect the Kidney in Children with Congenital Heart Disease Undergoing Cardiopulmonary Bypass

Remote Ischemic Preconditioning Protect the Kidney in Children with Congenital Heart Disease Undergoing Cardiopulmonary Bypass by up regulation of miR-21 mediated anti-inflammatory

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOC-15007513
Enrollment
Unknown
Registered
2015-11-23
Start date
2016-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute renal injury

Interventions

RIPC group or control group:Remote ischemic preconditioning was performed at 12 hours before surgery, which induced by four 5-min cycles of lower limb ischemia and 5-min reperfusion using a blood-pre

Sponsors

Hunan Children’s Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. children with congenital heart disease hospitalized between Jan. 1, 2016 and Dec. 31, 2016 in the Department of Cardiothoracic Surgery of Hunan Children's Hospital, Changsha, China; 2. 1 month~13 years old; 3. under elective CPB surgery; and 4. informed consent signed before surgery.

Exclusion criteria

Exclusion criteria: 1. patient with chromosome disease, malignant tumor, hematological system diseases, and diabetes; 2. patient with chronic renal disease; 3. patient with acute or chronic inflammatory diseases; 4. patient with preoperative AKI; and 5. patient administered with nephrotoxic drug during the disease course.

Design outcomes

Secondary

MeasureTime frame
NGAL;L-FABP;Cys C;KIM-1;—

Primary

MeasureTime frame
microRNA-21;TNF-alpha;Renal function;—

Contacts

Public ContactLi Zhihui
Lizh0731@aliyun.com+86 13875807019

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026