asthma
Conditions
Interventions
1:tiotropium
2:Placebo
Sponsors
Respiratory Department, Xinqiao Hospital (2nd Affiliated Hospital) of Third Military University, Chongqing
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Before any assessment, must sign an informed consent; 2. Male or female adults aged between 18-75 years old; 3. Under the existing GINA strategy (GINA2014), patients were diagnosed with asthma, and there is reversible within 1 year test positive result; 4. Use salbutamol 400ug (via a spacer inhalation) 30 minutes after the FEV1% post <80%; 5. 1 patient visits within 3 months before the law to accept the GINA recommendation Class IV treatment can not achieve asthma control; 6. The proportion of induced sputum eosinophils category <3%.
Exclusion criteria
Exclusion criteria: 1. associated with chronic obstructive pulmonary disease; 2. Before the patient visits a three-month internal any reason, systemic corticosteroid therapy, and treatment >7 days; 3. Patients with a prior visit occurred within 4 weeks of respiratory tract infections; 4. bronchiectasis patients with clinically significant or other clinically significant respiratory system and other system disorders; 5. Known for possible treatment of patients with drug allergy; 6. A pregnant or lactating women; 7. patients can not use a single dose dry powder inhaler device; 8. investigators determine poor patient compliance or other diseases are not suitable to participate in this study; 9. In a visit within the first 30 days or 5 half-lives (in a longer time) had used other experimental drugs; 10. The angle-closure glaucoma, symptoms of an enlarged prostate or bladder neck obstruction, creatinine clearance <50ml/ml in patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morning peak FEV1; | — |
Countries
China
Contacts
Public ContactWang Changzheng
Outcome results
None listed