General anesthesia
Conditions
Interventions
Control:Intranasal and intravenous saline
Intranasal dexmedetomidine:Intranasal dexmedetomidine and intravenous saline
Intravenous dexmedetomidine:Intranasal saline and intravenous dexmedetomidine
Sponsors
The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
Eligibility
Sex/Gender
Female
Age
40 Years to 55 Years
Inclusion criteria
Inclusion criteria: Aged 40-55 yr patients who scheduled for elective hysterectomy with ASA physical status I.
Exclusion criteria
Exclusion criteria: BMI larger than 30 kg/m2, heart diseases, hypertension, nasal diseases, recent use of sedative and analesic drugs, alcoholabuse, cerebral and mental illness patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect-site concentration of propofol in induction;Lowest effect-site concentration of propofol in maintenance;Highest effect-site concentration of propofol in maintenance;Propofol requirements in maintenance;Lowest effect-site concentration of remifentanil in maintenance;Highest effect-site concentration of remifentanil in maintenance;Remifentanil requirements in maintenance;Time to the first postoperative sufentanil dose;Sufentanil requirements 24h following surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| BIS values before target-controlled infused remifentanil;Number of patients required atropine and phenylephrine;The incidence of postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactDong-hua Shao
Outcome results
None listed