Nosocomial infection caused by KPC-producing K. pneumoniae
Conditions
Interventions
Study group:amoxicillin/ clavunalic acid in combination with cefepime
Control group:Tigecycline treatment
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
19 Years to 90 Years
Inclusion criteria
Inclusion criteria: Those patients who met with the follow standards were involved: (1) Adult patients aged from 18 to 90 years old; (2) Temperature should be over 38 degrees Celsius (oral) or armpit greater than 37.5 degrees Celsius; (3) Nosocomial infection was confirmed, which means infections, such as pneumonia, CNS infection, abdominal infection, urinary tract infection, skin and soft tissue infection and blood infection, should happened after48 hours of hospital addmission; (4) Treatment of anti-infection should continued over 48 hours; (5) Patient Informed consent file should be abtained in advance.
Exclusion criteria
Exclusion criteria: (1) Community-acquired infection should be excluded; (2) Contraindictions such as allergic reaction happen in the treatment; (3) Treatment of anti-infection continue less than 48 hours; (4) Pregnant women and lactating women; (5) Other related contraindictions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality;pathogen clearance rate;cost of the antibiotic treatment; | — |
Countries
China
Contacts
Public ContactYunsong Yu
Outcome results
None listed