Multiple Myeloma
Conditions
Sponsors
Department of Hematology, Changzheng Hospital, The Second Military Medical University.
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. patients diagnosed as relapsed or refractory multiple myeloma with CD138-positive isotype, who are ineligible for hematopoietic stem cell transplantation or unwilling to receive hematopoietic stem cell transplantation; 2. Aged 18 to 75 years; 3. patients with an expected survival3 months; 4. Sign the consent form; 5. Organ function: 1) heart function: NYHA functional class 92%; 6. Karnofsky score >=60, ECOG score <=2; 7. Medication history: not receiving any chemotherapy in the last one month,2)not receiving any immunotherapy in the last three months.
Exclusion criteria
Exclusion criteria: 1. Patients infected with bacteria, fungi, viruses and other microorganisms at present; 2. Unexplained fever, body temperature> 38 degree C; 3. Patients with HIV-positive; 4. Patients infected with active HBV and HCV; 5. patients developed Myocardial infarction and severe arrhythmia in the past six months; 6. Patients with congenital immune deficiency; 7. Patients and(or) their families do not accept CAR-T treatment; 8. patients with pregnancy or in lactating period; 9. Receiving steroid hormone agents during CAR-T treatment; 10. Receiving other anti-cancer agents during CAR-T treatment; 11. Patients with history of epilepsy or other mental disorders who are unable to obey the medical orders, or patients who are judged as not appropriate for CAR-T treatment by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ratio of bone marrow plasma cells;Monoclonal Immunoglobulin;Serum Free Light Chains;Urine Light Chain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin;ß2- microglobulin; | — |
Countries
China
Contacts
Public ContactJian Hou
Department of Hematology, The Myeloma & Lymphoma Center, Changzheng Hospital, The Second Military Medical University.
Outcome results
None listed