anastomotic fistula
Conditions
Interventions
treatment group:drug administration (rhEGF)
Sponsors
Zhujiang hospital of Southern Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Untreated patients without previous rectal surgery history; 2. Aged 18 to 60 years old; 3. Men or non pregnant,lactating women; 4. Pathological diagnosis is adenocarcinoma,diameter of tumor=3cm, distance from dentate line 3 to 5cm; 5. The new adjuvant chemotherapy has been successfully completed for 8 weeks.(2017 colorectal cancer NCCN guide); 6. Well nourished, ALB= 35 g/L, HGB=100 g/L; 7. The organ functions well, Biochemical tests meet the following conditions:ALT= 2.5×ULN,AST= 2.5×ULN,T-BiL= 1.5×ULN,Scr= 1.5×ULN; 8. Have signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Complete intestinal obstruction; 2. The frozen pelvic cavity was found before operation; 3. Long-term use of immunosuppressant or steroid drugs; 4. They also have severe or uncontrolled internal medical diseases and infections(AF,angina,cardiac insufficiency, The ejection fraction is less than 50%, Refractory hypertension, COPD, ect.); 5. Obese or overly alcoholic; 6. Severe or uncontrollable mental illness; 7. drug abuse,as well as medical, psychological or social conditions may interfere with patients' participation in the study or have an impact on the assessment of the results; 8. There is a history of severe ulcerative colitis or congenital macrocolic; 9. Allergic to natural and recombinant hEGF, glycerol, mannitol; 10. Tumor is widely metastasized and life is expected to be less than 6 months; 11. To participate in other clinical trials within three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| white blood cell;C-reactive protein;anastomotic healing condition;anastomotic healing condition; | — |
Countries
China
Contacts
Public ContactChunhui Cui
Zhujiang hospital of Southern Medical University
Outcome results
None listed