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Do we really need closed-suction drainage after an antibiotic-loaded spacer in two-stage revision of infected total joint arthroplasty

Do we really need closed-suction drainage after an antibiotic-loaded spacer in two-stage revision of infected total joint arthroplasty: A single-centered, prospective and randomized study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-17014162
Enrollment
Unknown
Registered
2017-12-26
Start date
2018-01-01
Completion date
Unknown
Last updated
2018-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prosthetic joint infection

Interventions

Group 1 : clamping closed-suction drainage
Group 2:open closed-suction drainage

Sponsors

Department of Orthopaedics, General Hospital of People's Liberation Army
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 75 years patients requiring antibiotic-loaded spacer; 2. All patients sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients participate another clinical study within 1 month; 2. Patients refuse to participate this study; 3. Patients are allergic to vancomycinmeropenem, tranexamic acid and bone cement; 4. Patients with hepatic or renal insufficiency; 5. Patients with coagulant function abnormality.

Design outcomes

Primary

MeasureTime frame
elution of vancomycin in drainage;elution of meropenem in drainage; Aintibacterial activities of drainage;—

Secondary

MeasureTime frame
perioperative hemoglobin;perioperative creatinine;perioperative glutamic-pyruvic transaminase;—

Countries

China

Contacts

Public ContactChen Jiying

General Hospital of People's Liberation Army

jiying_chen301@163.com+86 13901078832

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 20, 2026