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Effect of permissive hypercapnia on inflammation in infants undergoing one-lung ventilation

Effect of permissive hypercapnia on inflammation in infants undergoing one-lung ventilation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-17014047
Enrollment
Unknown
Registered
2017-12-20
Start date
2018-01-01
Completion date
Unknown
Last updated
2018-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

One-lung ventilation

Interventions

Hypercapnia:Permissive hyercapnia
Normocapnia:Normocapnia

Sponsors

Guangdong Women and Children Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 1 Years

Inclusion criteria

Inclusion criteria: Infants who going to undertake video-assisted thoracoscopic surgery, aged 1 to 12 months, weighed 4.1 to 12.1 kg, ASA classification between I to II, diagnosed infection or any other respiratory disease, and have no obvious abnormality in preoperative general examination (blood routine test, coagulation function, liver function, kidney function examination).

Exclusion criteria

Exclusion criteria: (1) failed to maintain SpO2 above 90% during OLV; (2) peak airway pressure (Ppeak) lower than 30 cmH2O during surgery; (3) duration of OLV less than 1 hour or the surgery last more than 3 hours; (4) intraoperative blood lost more than 20% of the total blood volume; (5) changed method of operation into thoracotomy.

Design outcomes

Primary

MeasureTime frame
IL-6;IL-8;Receptor for advanced glycation end products (RAGE);Arterial blood gas analysis;—

Countries

China

Contacts

Public ContactYongle Li

Department of Anesthesiology, Guangdong Women and Children Hospital

muzirno@hotmail.com+86 1802638161

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026