Chronic kidney disease
Conditions
Interventions
placebo group:Oral placebo
probiotic group:Oral L. casei Zhang
Sponsors
Tongji Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Aged 18-75 years old; 2.In line with KDIGO diagnosis of chronic kidney disease staging standards; 3.CKD stage 3-5, did not receive dialysis treatment, no dialysis indications, temporary stable condition, the drug can control the stage; 4.To be informed and volunteer to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating; 2. Female patients who did not use any contraception; 3. Vital signs unstable, unstable patients; 4. There are difficult to correct hyperkalemia, heart failure and other indicators of dialysis emergency dialysis; 5. After uncontrolled by conservative medical treatment, one of the following conditions is still excluded: Hb <70g / L; or carbon dioxide binding strength <13mmol / L; 6. With active malignancy, stroke, myocardial infarction and other serious primary diseases; 7. Have gastrointestinal bleeding, irritable bowel syndrome, Crohn's disease or ulcerative colitis and other gastrointestinal diseases, history of gastrointestinal surgery patients with history; 8. Patients with a history of mental illness; 9. There is a history of renal transplantation or kidney transplantation within 6 months; 10 in the past 1 month to take antibiotics, glucocorticoids or other immunosuppressive agents, including probiotics, prebiotics of food, medicine and other patients; 11. The test sample allergy or obvious gastrointestinal symptoms such as those who can not tolerate; 12. Patients who receive other clinical trials at the same time; 13. The researcher can not confirm the completion of the researcher on time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creatinine;Indoxyl sulfate;P-cresyl sulfate; | — |
Countries
China
Contacts
Public ContactYing Yao
Tongji Hospital
Outcome results
None listed