postoperative analgesia in children
Conditions
Interventions
Group H(0.1mg/kg hydromorphone):postoperative analgesia with 0.1mg/kg/48h of hydromorphine
Group H2(0.2mg/kg hydromorphone):postoperative analgesia with 0.2mg/kg/48h of hydromorphine
Group C(sulfentanyl):postoperative analgesia with 1.5ug/kg/48h of sulfentanyl
Sponsors
Guangzhou Women and Children Medical Center
Eligibility
Sex/Gender
All
Age
0.5 Years to 3 Years
Inclusion criteria
Inclusion criteria: 1) the age was from 6m to 3Y, and the sex was not limited. 2) children who have been anesthetized by tracheal intubation are grade I - II of ASA anesthesia. 3) children undergoing elective abdominal surgery (open or laparoscopic), anorectal surgery, Department of orthopedics surgery, Department of five and Urology; 4) children's parents or legal guardians have signed informed consent
Exclusion criteria
Exclusion criteria: 1) children with hypersensitivity to hydromorphine hydrochloride or a group of anaphylaxis with opioid allergies; 2) preoperative 24h use of sedative and analgesic and antiemetic and anti itch drugs; 3) children with acute upper respiratory tract infection before operation; 4) children with a history of bronchial asthma; 5) children with severe sleep apnea syndrome and children with arrhythmia; 6) history of previous anaesthesia with abnormal surgery; preoperative assessment of the presence or possible existence of difficult airway 7) renal function injury (BUN and / or upper limit of Cr> normal value); liver function injury (ALT and / or AST>1.5 times upper limit of normal value); 8) children with related mental and neurological diseases, which are difficult to evaluate the analgesic effect. 9) children with chronic pain history or long-term use of painkillers; 10) severely obese children or preterm infants who have been corrected for six months of age 11) children with other cases that are considered unsuitable for admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score;remedial administration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay score;The first remedial time for analgesic administration;Total satisfaction of 48h analgesia;vital signs; | — |
Countries
China
Contacts
Public ContactXingrong Song
Guangzhou Women and Children Medical Center
Outcome results
None listed