meibomian gland dysfunction
Conditions
Interventions
1:LipiFlow
2:Hot compress
Sponsors
Beijing Tongren Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 18 years and more, male or female; 2. Strictly implement the informed consent process of the subject, the subject's consent must be read, signed and dated by the subject, host or designated person; 3. Subjective dry eye symptoms using the SPEED questionnaire, each eye symptoms score 6 points or higher; 4. Both eyes were meibomian gland dysfunction. Fifteen glands of the lower eyelid, meiyal gland lipid secretion score (MGYLS) of 12 or less (range, 0-45) were evaluated for each eye; 5. Cooperate with the test testing process, if assigned to the control group, abide to do hot compress treatment at home; 6. To be able to complete all visits and follow-ups.
Exclusion criteria
Exclusion criteria: 1. SPEED score of 15 or above; 2. More than 50% glandular defects of lower eyelid meibomian glands are found in the meibomian gland photography; 3. Concomitant ocular diseases that can result in increased therapeutic damage, such as ocular infection or inflammation in any one eye; ocular surgery or trauma within the first trimester of baseline examinations; and the abnormality of ocular surface affecting corneal integrity of any one eye; eyelid abnormalities affecting eyelid function in either eye; 4. Dry eye caused by systemic disease and unwillingness to abandon systemic drug therapy that leads to dry eye during the study; 5.The punctum puncture placement or lacrimal ductoplasty within three months before baseline examination. If a subject with a punctum plug or tear tube angioplasty was performed three months earlier, a new punctal plug was not allowed to be placed or lacrimal ductoplasty during the study; 6. Participate in other ophthalmic clinical trials involving the treatment of medications or medical devices within 30 days prior to baseline examinations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient's symptoms (SPEED and OSDI questionnaire);tear break-up time (TBUT);Meibomian gland opening evaluation (MGE);Lipid layer thickness (LLT); | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of meibomian glandular photography;Fluorescein staining in cornea and conjunctiva;Incomplete blink frequency (PB);Corneal Sensitivity; | — |
Countries
China
Contacts
Public ContactWang Ningli
Beijing Tongren Hospital, Capital Medical University
Outcome results
None listed