Chronic Kidney Disease
Conditions
Interventions
intervention group A:receive Oligofructose-enriched inulin
intervention group B:receive maltodextrin
Sponsors
TongJi Medical College Of Huazhong University Of Science & Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: patients with an estimated glomerular filtration rate (eGFR) lower than 15 ml/min/1.73 m2, receiving CAPD treatment longer than 3 months, aged between 18 and 65 years and able to provide informed consent.
Exclusion criteria
Exclusion criteria: Patients will be excluded if they meet any of the following criteria: with a diagnosis of diabetes mellitus; consumed antibiotic therapy within 1 month of study commencement; receiving/or have received radiation to the bowel or large bowel resection; medically diagnosed irritable bowel syndrome, Crohns disease or ulcerative colitis; severely malnourished (Subjective Global Assessment > 15); having had a clinically significant change to their immunosuppressant dose within 6 months (determined by the medical team).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Indoxyl sulfate in serum, dialysate, urine and fecal samples; | — |
Secondary
| Measure | Time frame |
|---|---|
| p-cresyl sulfate n serum, dialysate, urine and fecal samples;estimate glomerular filtration rate,proteinuria, albuminuria and ß-2 microglobulin in 24-h urine ;microbiological analysis in stool samples;weekly total urea clearance (Kt/V) and weekly total creatinine clearance (Ccr);dietary protein and fiber intake;Serum albumin, prealbumin,the subjective global assessment score;serum including hs-CRP, interleukin6 (IL-6) and tumor necrosis factor-a (TNF-a);blood pressure, total cholesterol (TC), total triacylglycerol (TG), Low density lipoprotein (LDL), High density lipoprotein (HDL) and short chain fatty acids (SCFA) and serum carboxy methyl lysine; | — |
Countries
China
Contacts
Public ContactXuezhi Zuo
Tongji Hospital, Tongji Medical College, Huazhong University Science and Technology
Outcome results
None listed