gastrointestinal disease and anesthesia in old patients
Conditions
Interventions
G(S+P):sufentanyl+propofol
G(D+P):dexmedetomidine+propofol
G(K+P):katamine+propofol
G(N+P):Physiological saline+propofol
Sponsors
Anesthesiology Dept. Shenzhen Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 60 and 80 years old; 2. ASA class for II-III; 3. BMI18kg/m^2-30 kg/m^2; 4. Planing to receive gastroscopy From September 2017 to October 2017; 5. The patient or family member fully understood the purpose and significance of this experiment, volunteered to participate in this clinical trial, and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Neurological dysfunction, Glasgow coma score (GCS) was less than 12 points; 2. Diabetic patients with no satisfactory control of blood glucose and blood pressure (random blood glucose in the screening period is greater than 11.1 mmlol/L) and hypertension patients (blood pressure is higher than 160mmHg). 3. There was a history of myocardial infarction and unstable angina in 6 months; 4, screening period exist bradycardia (heart rate 50 times per minute or less), III degree atrioventricular block (use of pacemaker patients), and other serious arrhythmia history; 5. Systolic pressure is less than 90 mmHg or patients with vasoactive drugs; 6. Patients with mental disorders (such as schizophrenia, depression, etc.) and cognitive dysfunction patients with a history of epilepsy, as well as patients with history of psycho-drug abuse and drug abuse; 7. the coagulation function abnormality (PT or INR, APTT>1.5 times normal value upper limit), has bleeding tendency (such as the active digestive tract ulcer) or is receiving thrombolytic or anticoagulant therapy; 8. abnormal liver function, ALT or AST>2 times normal value upper limit;Total bilirubin >1.5 times normal value upper limit; 9. Renal function abnormality, blood creatinine (cr) and/or urea nitrogen (BUN) >1.5 times normal value upper limit;Dialysis patients; 10. Patients with severe snoring or sleep apnea syndrome; 11. Patients who are allergic to the drugs used in this study or in the range of drug contraindications; To participate in clinical trials of other drugs within 12 or 3 months; 13. The researchers judged that the patient was not suitable for other situations in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate;blood pressure;Oxygen saturation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The BIS value;ETCO2;Ramsay sedation scores; | — |
Countries
China
Contacts
Public ContactYoutan Liu
Shenzhen Hospital, Southern Medical University
Outcome results
None listed