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A clinical study for determine the effect of rhubarb, Coptis chinensis and dried ginger in regulation of peritoneal dialysis patients' intestinal flora and its metabolites

A clinical study for determine the effect of rhubarb, Coptis chinensis and dried ginger in regulation of peritoneal dialysis patients' intestinal flora and its metabolites based on Professor Huang Chunlin's theory of regulating the spleen and stomach

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-17013624
Enrollment
Unknown
Registered
2017-11-30
Start date
2017-12-01
Completion date
Unknown
Last updated
2017-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic renal failure (Uremia Stage)

Interventions

Chinese Herbal Medicine:Rheum officinale 5g, Rhizoma Coptidis 5g, Rhizoma zingiberis 5g (granule)
Western Medicine Group:Triple viable bifidobacterium capsules

Sponsors

Guangdong Provincial Hosptial of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Chronic renal failure (Uremia Stage), had already maintained peritoneal dialysis for more than 2 months; 2. Aged between 18-80 years old; 3. No hormone, antibiotics nor any drugs of regulating intestinal flora have been taken for the past three months.

Exclusion criteria

Exclusion criteria: 1. Occur acute complications, such as acute heart failure, infections (pulmonary infection, intestinal infection, urinary tract infection, peritonitis), etc.; 2. Occur Severe intestinal diseases, such as irritable bowel syndrome, colitis gravis, gastrointestinal hemorrhage, etc.; 3. Pregnant and lactating women.

Design outcomes

Primary

MeasureTime frame
Classification of gastrointestinal symptoms;Change of TCM symptom;Determination of intestinal flora;LPS;Indoxyl sulfatc (IS);P-crcsyl sulfatc (PSC);

Secondary

MeasureTime frame
BRT;ALB;pre-ALB;CRP;SF;Na;K;Cl;P;Scr;Urea;TCO2CP;UA;ALT;AST;SRT;PET;Kt/V;

Countries

China

Contacts

Public ContactYu Peng

Guangdong Provincial Hosptial of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine)

pengyu313@sina.com+86 13622277315

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026