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Conditions
Interventions
B:DAAs combined with UC-MSCs
A:DAAs
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. male or female aged from 18 to 65 years; 2. The patients met the diagnostic criteria for hepatitis C according to the 2015 guidelines for the prevention and treatment of hepatitis C and met the following conditions of decompensation: (1) Child-puph B (7 - 9) or C (10 - 15); (2) any of evidence of chronic liver insufficiency: Hepatic encephalopathy; Serum total bilirubin >51umol/L; PT>5s d.serum albumin <28g/L; moderate or severe ascites; (3) happened esophagealgastricavariceal bleeding, spontaneous peritonitis. 3. The detection of HCV RNA was positive.
Exclusion criteria
Exclusion criteria: 1. History of antiviral, antitumor or immunosuppressive drugs use in the previous 6 monthes; 2. Pregnant or lactating women or a birth plan during treatment; 3. Co-infection with other viruses (hepatitis A, B or E, or HIV); 4. Other causes of chronic liver diseases (e.g., autoimmune liver disease, alcoholic liver disease, drug induced liver injury, hereditary metabolic liver disease,etc.); 5. Co-existing hepatocellular carcinoma or AFP >100 ng/mL; 6. Other malignancies; 7. Serious diseases in other organ systems (e.g.,renal impairment: urine proteinserum(+), creatinine>116umol/L, etc.); 8. Intolerance to the medical treatments mentioned above; 9. The patients who will receive bioartificial liver support therapy or liver transplantation; 10. Disagreement to informed consent; 11. The researchers considered inappropriate to participate in the study because of other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MELD; | — |
Countries
China
Contacts
Public ContactXiaohong Zhang
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed