diabetic retinopathy
Conditions
Interventions
intravitreal injection of Lucentis:intravitreal injection of Lucentis
intravitreal injection of Lucentis combined with PRP laser treatment:intravitreal injection of Lucentis combined with PRP laser treatment
PRP laser treatment:PRP laser treatment
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Signd the informed consent form can be followed up according to the test plan; 2. Target eye with stage IV diabetic retinopathy: retinal neovascularization (NVE) or optic disc neovascularization (NVD), when NVD > 1/4-1/3DA or NVE is greater than 1/2DA, or with anterior retinal hemorrhage or vitreous hemorrhage, is called high-risk proliferative phase"; 3. Aged over 18 weeks, male and female; 4. Patient confirmed with diabetes whose blood sugar been controlled and stable; 5. glycosylated hemoglobin (HbAlc) less than 8.0%.
Exclusion criteria
Exclusion criteria: 1. Patients who have been treated with laser therapy; 2. Patients with severe cataracts, glaucoma or ocular active inflammation; 3. The target eye has traction retinal detachment, with or without vitreous hemorrhage; the target eye has been accepted within 3 months before the screening, or need intraocular surgery during the study period; 4. The affected eye is the only functional eye; 5. The target eye is associated with other retinal diseases, including central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO), ocular ischemic syndrome, hypertensive retinopathy, etc.; 6. Target eye, non target eye or whole body system were treated with anti vascular endothelial growth factor (VEGF) TA and other drugs within 3 months before screening; 7. Preoperative routine examination results are abnormal, not suitable for eye surgery; 8. The researchers found that they were not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EDTRS visual acuity test;Ultra wide angle fundus photography;Ultra wide angle fundus shadow;Color Optical Coherence Tomography;optometry; | — |
Countries
China
Contacts
Public ContactFu Min
Zhujiang Hospital of Southern Medical University
Outcome results
None listed