Diabetic foot chronic wound
Conditions
Interventions
Control:Palliative debridement
Experimental group:Wound dressing change
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years old; 2. 1-2 Wagner grade of diabetic foot; 3. with ulcers for at least 4 weeks or above; 4. The area of skin defect after debridement range from 1 to 20cm2; 5. The subject or his legal agent understands the purpose and the necessary procedures of this study, and is willing to participate in this study with the signature of the informed consent form.
Exclusion criteria
Exclusion criteria: 1. ulcers caused by scalds, burns, and radioactive damage; 2. ulcers caused by varicose veins; 3. Malignant lesions in foot ulcers; 4. Ankle brachial index (ABI) 1.3; 5. Diabetic foot Wagner grade 0, grade 3 and above; 6. Patients with serious disease in the system of heart, liver, lung, kidney or blood, or with acute attack of chronic disease, or with fasting blood-glucose = 10mmol/L, or with blood pressure > 140/90mmHg, or with hemoglobin 300×10^9/L, or with coagulation abnormalities, or with abnormal cardiac function, or with abnormal liver function, or with abnormal renal function, or with malnutrition; 7.Patients have received glucocorticoids, drugs that affect platelet function, immunosuppressor, radiotherapy or chemotherapy within 3 months, or need to receive with the aforementioned treatment during the study period; 8. Patients with mental disorders or cancers; 9. Pregnant or lactating women; 10. Patients have participated in other clinical trials within three months; 11. Patients are regarded as be ineligible for the participation in this research by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The infection rate;Amputation (toe) rate; | — |
Countries
China
Contacts
Public ContactZhang Peihua
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed