bipolar disorder
Conditions
Interventions
Deep-brain magnetic stimulation:Patients in this arm will receive 14 days of active DMS, twice a day.
sham stimulation:Patients in this arm will receive 14 days of sham stimulation, twice a day.
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Inpatients/Out-patients, male or female, aged 18 to 60 years (including 18 years and 60 years); 2. Meet the diagnosis standard of Bipolar disorder (ICD-10), current episode depressed without psychotic features; 3. Having 17-item Hamilton Depression Rating Scale (HAMD-17) total score = 14; 4. Primary school or above education background, to be able to understand the content of the questionaire; 5. Signed informed consent by patient him/her self.
Exclusion criteria
Exclusion criteria: 1. Have been diagnosed of schizophrenia, schizoaffective disorder or other mental disorders associated with diseases; 2. Have alcohol/drug dependence or acute poisoning within 1 year; 3. Pregnant or lactating women; 4. Currently have a serious risk of suicide judged by investigators; 5. Currently have severe physical illnesses which researchers think it is risky and not eligible to participate; 6. Previously not tolerate to lithium carbonate; 7. Have been treated with lithium carbonate with daily dose of more than 0.75g and continuous use of more than 14 days before entering the study; 8. Have been treated with fluoxetine or antipsychotic long-acting injection within 30 days; 9. Currently have kidney diseases; 10. Have thyroid dysfunction or currently on hormone therapy before enrollment; 11. With history of craniocerebral injury or nervous system or repeated episodes of headache; 12. Recent history (within 1 year) of ECT or MECT treatment; 13. Have metal objects embedded in the body can not be removed, such as dentures, artery clips, pacemakers or metal fixtures, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change of HAMD-17 total score;Change of Electroencephalogram, magnetic resonance brain imaging examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| response rate;Remission rate; | — |
Countries
China
Contacts
Public ContactXiao Le
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed