cesarean scar defect (CSD)
Conditions
Interventions
Control:Single dose of cefuroxime (2.0g /50ml NaCl0.9 %) and placebo 50ml NaCl0.9 % ivggt
Experimental group:Single dose cefuroxime (2.0g /50ml NaCl0.9 %) with a single dose of azithromycin (0.5 g/50ml NaCl0.9 %)
Sponsors
The International Peace Maternity & Child Health Hospital affiliated to Shanghai JiaoTong university
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Han nationality, Aged between 20 to 40 years old, gestational age= 37 weeks, or preoperative fibrinogen acuity =2.0 g/L, preoperative platelet= 100*10^9/L or higher, preoperative hemoglobin = 90 g/L.
Exclusion criteria
Exclusion criteria: 1. disagree of informed consent; 2. known allergies to the azithromycin (including other macrolides antibiotic) or cefuroxime (including other second generation cephalosporins); 3. the patients finally reached vaginal delivery; 4. no used of azithromycin, within 7 days before randomization; 5. vaginal group B hemolytic streptococcus (GBS) positive; 6. chorioamnionitis or other postoperative supplementary use of antibiotics; 7. stillbirth; 8. severe liver and kidney dysfunction (liver cirrhosis or liver enzyme increased three times or more than normal ceiling or serum creatinine greater than or equal to 2.0 mg or 177 umol/L); 9. diarrhea when planning into the randomization; 10. myocarditis; 11. pulmonary edema; 12. maternal structural heart disease, or need to use the antiarrhythmic drugs for the heart disorders; 13. diagnosis of uterine anomalies before, such as abnormal uterus (uterus unicornis, mediastinum uterus, double uterus, uterus bicornis) and uterine fibroids or adenomyosis; 14. those who have rheumatoid arthritis or other special conditions with joint pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cesarean scar defect; | — |
Secondary
| Measure | Time frame |
|---|---|
| CBC;CRP;PCT;coagulation function; | — |
Countries
China
Contacts
Public ContactDing Huang
The International Peace Maternity & Child Health Hospital affiliated to Shanghai JiaoTong university
Outcome results
None listed