Thyroid eye disease
Conditions
Interventions
1:Transnasal decompression surgery
2:Transorbital decompression surgery
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18-70 years old, male or female; 2. Diagnosed with TED; 3. Underwent orbital decompression due to disfiguring proptosis, exposure keratitis or DON 4. Normalized thyroid function for at least 3 months before included: including those who are taking anti hyperthyroidism drugs or without taking medication, FT3, FT4 normal, TSH normal or lower; 5. CAS score = 3 points and unchanged proptosis (changes =1mm between 2 visits) for at least 3 months; 6. Proptosis =18 mm.
Exclusion criteria
Exclusion criteria: 1. Severe disease of heart, liver and kidney function failure including myocardial ischemia or myocardial infarction, arrhythmia and heart failure; ALT, AST more than 1.5 times the upper limit of the normal value; creatinine level over normal limit or eGFR < 60 ml/min/1.73 M2); 2. Diabetes or other autoimmune diseases, uncontrolled hypertension, tuberculosis, mental disease patients; 3. Patients with positive pregnancy test; 4. Patients with abnormal nasal structure; 5. Other reasons leading to contraindications to surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative proptosis reduction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diplopia and Strabismus;Ocular restriction;Visual acuity;Surgical time;hospital day; | — |
Countries
China
Contacts
Public ContactHuifang Zhou
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed