Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Control:six-minute walking test
High flow nasal cannula:High flow nasal cannula
Negative pressure ventilation:Negative pressure ventilation
Sponsors
Taipei MacKay memorial hospital respiratory therapy department
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Clinicians diagnosed with chronic obstructive pulmonary disease, the cause of this wish for acute exacerbation of chronic obstructive pulmonary disease; 2. Disease symptoms include the following: a chronic cough, cough with sputum, increased sputum, sputum removal difficulties, difficulty breathing or shortness of breath affect the daily life activities, there is insufficient ventilation (PaCO2> 40mmHg) or hypoxia (PaO2 (FEV1 / FVC 40mmHg) or hypoxia (PaO2 (FEV1 / FVC 40mmHg) or hypoxia (PaO2 (FEV1 / FVC 40mmHg) or hypoxia (PaO2 (FEV1 / FVC 40mmHg) or hypoxia (PaO2 (FEV1 / FVC <70%), lung function showed moderate to moderate obstruction (FEV1 / FVC <70%), daily activity or calm and blood oxygen saturation (SpO2 <90%) decreased; 3. The patient, the agent, or the family member who has the right of consent to understand and are willing to sign the consent of the subject.
Exclusion criteria
Exclusion criteria: 1. The patient, the agent or the family of the consenter is unwilling to sign the consent of the subject; 2. Those who do not meet the subject's condition; 3. unstable signs of life: heartbeat (more than 150 minutes per minute or less than 40), the number of breathing (per minute; At 40 or less than 10 per minute), blood pressure (mean arterial pressure less than 70 mmHg). 4. There are epilepsy re-state, acute brain injury, acquired immunization, pneumothorax and highly contagious disease, heart rhythm; Not likely to receive heart beat patients. 5. Recent patients with angina, myocardial infarction or severe pulmonary hypertension; 6. Any skeletal muscle dysfunction can not perform the movement of the patient; 7. Serious hypoglycemic or patients with hypoxia caused by exercise and who can not be improved by the use of oxygen; 8. There are mental illnesses.;Exclusion criteria: 1. The patient, the agent or the family of the consenter is unwilling to sign the consent of the subject; 2. Those who do not meet the subject's condition; 3. unstable signs of life: heartbeat (more than 150 minutes per minute or less than 40), the number of breathing (per minute; At 40 or less than 10 per minute), blood pressure (mean arterial pressure less than 70 mmHg). 4. There are epilepsy re-state, acute brain injury, acquired immunization, pneumothorax and highly contagious disease, heart rhythm; Not likely to receive heart beat patients. 5. Recent patients with angina, myocardial infarction or severe pulmonary hypertension; 6. Any skeletal muscle dysfunction can not perform the movement of the patient; 7. Serious hypoglycemic or patients with hypoxia caused by exercise and who can not be improved by the use of oxygen; 8. There are mental illnesses.;Exclusion criteria: 1. The patient, the agent or the family of the consenter is unwilling to sign the consent of the subject; 2. Those who do not meet the subject's condition; 3. unstable signs of life: heartbeat (more than 150 minutes per minute or less than 40), the number of breathing (per minute; At 40 or less than 10 per minute), blood pressure (mean arterial pressure less than 70 mmHg). 4. There are epilepsy re-state, acute brain injury, acquired immunization, pneumothorax and highly contagious disease, heart rhythm; Not likely to receive heart beat patients. 5. Recent patients with angina, myocardial infarction or severe pulmonary hypertension; 6. Any skeletal muscle dysfunction can not perform the movement of the patient; 7. Serious hypoglycemic or patients with hypoxia caused by exercise and who can not be improved by the use of oxygen; 8. There are mental illnesses.;Exclusion criteria: 1. The patient, the agent or the family of the consenter is unwilling to sign the consent of the subject; 2. Those who do not meet the subject's condition; 3. unstable signs of life: heartbeat (more than 150 minutes per minute or less than 40), the number of breathing (per minute; At 40 or less than 10 per minute), blood pressure (mean arterial pressure less than 70 mmHg). 4. There are epilepsy re-state, acute brain injury, acquired immunization, pneumothorax and highly contagious disease, heart rhythm; Not likely to receive heart beat patients. 5. Recent patients with angina, myocardial infarction or severe pulmonary hypertension; 6. Any skeletal muscle dysfunction can not perform the movement of the patient; 7. Serious hypoglycemic or patients with hypoxia caused by exercise and who can not be improved by the use of oxygen; 8. There are mental illnesses.;Exclusion criteria: 1. The patient, the agent or the family of the consenter is unwilling to sign the consent of the subject; 2. Those who do not meet the subject's condition; 3. unstable signs of life: heartbeat (more than 150 minutes per minute or less than 40), the number of breathing (per minute; At 40 or less than 10 per minute), blood pressure (mean arterial pressure less than 70 mmHg). 4. There are epilepsy re-state, acute brain injury, acquired immunization, pneumothorax and highly contagious disease, heart rhythm; Not likely to receive heart beat patients. 5. Recent patients with angina, myocardial infarction or severe pulmonary hypertension; 6. Any skeletal muscle dysfunction can not perform the movement of the patient; 7. Serious hypoglycemic or patients with hypoxia caused by exercise and who can not be improved by the use of oxygen; 8. There are mental illnesses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| six-minute walking distance;Modified Medical Research Council;Peak Inspiratory Pressure;Peak Expiratory Pressure; | — |
Countries
China
Contacts
Public ContactTung, Lan-fang;Tung, Lan-fang;Tung, Lan-fang;Tung, Lan-fang;Tung, Lan-fang ;;;;
Taipei MacKay memorial hospital respiratory therapy department;Taipei MacKay memorial hospital respiratory therapy department;Taipei MacKay memorial hospital respiratory therapy department;Taipei MacKay memorial hospital respiratory therapy department;Taipei MacKay memorial hospital respiratory therapy department
Outcome results
None listed