pulmonary dysfunction after cardiopulmonary bypass
Conditions
Interventions
protective ventilation group:small tidal volume ventilation
protective ventilation group:alveolar recruitment maneuver using incremental PEEP
protective ventilation group:ventilated with optimal PEEP
Sponsors
Department of Anesthesiology and Critical Care Medicine, Xin Hua Hospital affiliated to Shanghai Jiaotong University School of Medicine,China.
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: We will recruit 120 patients (year=1) that undergo the radical surgery therapy through median sternotomy with CPB in this study. The patients who undergo the surgery without CPB (ligation of patent ductus arteriosus, coarctation of aorta) or with the palliative surgery(pulmonary artery banding, systemic-to-pulmonary shunting) will not recruited in our study. The written consent from the childrens statutory guadians should be obtained before the recruitement.;Inclusion criteria: We will recruit 120 patients (year=1) that undergo the radical surgery therapy through median sternotomy with CPB in this study. The patients who undergo the surgery without CPB (ligation of patent ductus arteriosus, coarctation of aorta) or with the palliative surgery(pulmonary artery banding, systemic-to-pulmonary shunting) will not recruited in our study. The written consent from the childrens statutory guadians should be obtained before the recruitement.;Inclusion criteria: We will recruit 120 patients (year=1) that undergo the radical surgery therapy through median sternotomy with CPB in this study. The patients who undergo the surgery without CPB (ligation of patent ductus arteriosus, coarctation of aorta) or with the palliative surgery(pulmonary artery banding, systemic-to-pulmonary shunting) will not recruited in our study. The written consent from the childrens statutory guadians should be obtained before the recruitement.;Inclusion criteria: We will recruit 120 patients (year=1) that undergo the radical surgery therapy through median sternotomy with CPB in this study. The patients who undergo the surgery without CPB (ligation of patent ductus arteriosus, coarctation of aorta) or with the palliative surgery(pulmonary artery banding, systemic-to-pulmonary shunting) will not recruited in our study. The written consent from the childrens statutory guadians should be obtained before the recruitement.;Inclusion criteria: We will recruit 120 patients (year=1) that undergo the radical surgery therapy through median sternotomy with CPB in this study. The patients who undergo the surgery without CPB (ligation of patent ductus arteriosus, coarctation of aorta) or with the palliative surgery(pulmonary artery banding, systemic-to-pulmonary shunting) will not recruited in our study. The written consent from the childrens statutory guadians should be obtained before the recruitement.
Exclusion criteria
Exclusion criteria: 1. The childrens statutory guadians refuse to sign informed consent perioperatively; 2. The children have residual intracardiac shunt right to left diagnosed by transesophageal ultrasonic examination(TEE) intraoperatively or by echocardiography examination postoperatively; 3. The children are left ventricular dysfunctional [defined as left ventricular ejection fraction (LVEF )<50%]diagnosed by echocardiography postoperatively; 4. The children have severe complications during protective lung ventilation intervention( defined as the complications can not be relieved with the conventional dose of vasoactive agents or chest drainage, and last at least 3 minutes as well), including hypotension, bradycardia, arrhythemia, pneumothorax and pneumomediastinum.;Exclusion criteria: 1. The childrens statutory guadians refuse to sign informed consent perioperatively; 2. The children have residual intracardiac shunt right to left diagnosed by transesophageal ultrasonic examination(TEE) intraoperatively or by echocardiography examination postoperatively; 3. The children are left ventricular dysfunctional [defined as left ventricular ejection fraction (LVEF )<50%]diagnosed by echocardiography postoperatively; 4. The children have severe complications during protective lung ventilation intervention( defined as the complications can not be relieved with the conventional dose of vasoactive agents or chest drainage, and last at least 3 minutes as well), including hypotension, bradycardia, arrhythemia, pneumothorax and pneumomediastinum.;Exclusion criteria: 1. The childrens statutory guadians refuse to sign informed consent perioperatively; 2. The children have residual intracardiac shunt right to left diagnosed by transesophageal ultrasonic examination(TEE) intraoperatively or by echocardiography examination postoperatively; 3. The children are left ventricular dysfunctional [defined as left ventricular ejection fraction (LVEF )<50%]diagnosed by echocardiography postoperatively; 4. The children have severe complications during protective lung ventilation intervention( defined as the complications can not be relieved with the conventional dose of vasoactive agents or chest drainage, and last at least 3 minutes as well), including hypotension, bradycardia, arrhythemia, pneumothorax and pneumomediastinum.;Exclusion criteria: 1. The childrens statutory guadians refuse to sign informed consent perioperatively; 2. The children have residual intracardiac shunt right to left diagnosed by transesophageal ultrasonic examination(TEE) intraoperatively or by echocardiography examination postoperatively; 3. The children are left ventricular dysfunctional [defined as left ventricular ejection fraction (LVEF )<50%]diagnosed by echocardiography postoperatively; 4. The children have severe complications during protective lung ventilation intervention( defined as the complications can not be relieved with the conventional dose of vasoactive agents or chest drainage, and last at least 3 minutes as well), including hypotension, bradycardia, arrhythemia, pneumothorax and pneumomediastinum.;Exclusion criteria: 1. The childrens statutory guadians refuse to sign informed consent perioperatively; 2. The children have residual intracardiac shunt right to left diagnosed by transesophageal ultrasonic examination(TEE) intraoperatively or by echocardiography examination postoperatively; 3. The children are left ventricular dysfunctional [defined as left ventricular ejection fraction (LVEF )<50%]diagnosed by echocardiography postoperatively; 4. The children have severe complications during protective lung ventilation intervention( defined as the complications can not be relieved with the conventional dose of vasoactive agents or chest drainage, and last at least 3 minutes as well), including hypotension, bradycardia, arrhythemia, pneumothorax and pneumomediastinum.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2/FiO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ppeak;Cdyn;A-aDO2;Pa-ETCO2; | — |
Countries
China
Contacts
Public ContactSun Yuan;Sun Yuan;Sun Yuan;Sun Yuan;Sun Yuan ;;;;
Department of Anesthesiology and Critical Care Medicine, Xin Hua Hospital affiliated to Shanghai Jiaotong University School of Medicine,China.;Department of Anesthesiology and Critical Care Medicine, Xin Hua Hospital affiliated to Shanghai Jiaotong University School of Medicine,China.;Department of Anesthesiology and Critical Care Medicine, Xin Hua Hospital affiliated to Shanghai Jiaotong University School of Medicine,China.;Department of Anesthesiology and Critical Care Medicine, Xin Hua Hospit
Outcome results
None listed