infertility
Conditions
Interventions
first COS group:nothing
repeated COS group:palcebo
repeated COS and Chinese medcine group:Chinese medicine
Sponsors
Hebei University of Chinese Medcine
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: (1) Infertility women; (2) Meet the diagnostic criteria of kidney deficiency syndrome; (3) Aged 35 years old or less; (4) Regular menstruation (25-35 days); (5) Basic FSH< 10miu/ml, basic FSH/LH< 3.6; (6) The COS frequency was 3-5 times and the control group was the first COS; (7) Signed the informed consent.;Inclusion criteria: (1) Infertility women; (2) Meet the diagnostic criteria of kidney deficiency syndrome; (3) Aged 35 years old or less; (4) Regular menstruation (25-35 days); (5) Basic FSH< 10miu/ml, basic FSH/LH< 3.6; (6) The COS frequency was 3-5 times and the control group was the first COS; (7) Signed the informed consent.;Inclusion criteria: (1) Infertility women; (2) Meet the diagnostic criteria of kidney deficiency syndrome; (3) Aged 35 years old or less; (4) Regular menstruation (25-35 days); (5) Basic FSH< 10miu/ml, basic FSH/LH< 3.6; (6) The COS frequency was 3-5 times and the control group was the first COS; (7) Signed the informed consent.;Inclusion criteria: (1) Infertility women; (2) Meet the diagnostic criteria of kidney deficiency syndrome; (3) Aged 35 years old or less; (4) Regular menstruation (25-35 days); (5) Basic FSH< 10miu/ml, basic FSH/LH< 3.6; (6) The COS frequency was 3-5 times and the control group was the first COS; (7) Signed the informed consent.;Inclusion criteria: (1) Infertility women; (2) Meet the diagnostic criteria of kidney deficiency syndrome; (3) Aged 35 years old or less; (4) Regular menstruation (25-35 days); (5) Basic FSH< 10miu/ml, basic FSH/LH< 3.6; (6) The COS frequency was 3-5 times and the control group was the first COS; (7) Signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Uterus does not have function of pregnancy or serious body disease cannot bear, suffering from severe mental disorders, pregnancy infections, sexually transmitted disease, genitourinary system, has the serious bad habits such as drug abuse, the amount of contact with birth defects rays, or poison and is in effect; (2) Endometriosis, uterine fibroids, tuberculosis, intrauterine adhesions, endometrial lesions; (3) Polycystic ovary syndrome, ovarian cyst, fallopian tube water; (4) Not conforming to the inclusion criteria, can't take medicine as prescribed, etc.;Exclusion criteria: (1) Uterus does not have function of pregnancy or serious body disease cannot bear, suffering from severe mental disorders, pregnancy infections, sexually transmitted disease, genitourinary system, has the serious bad habits such as drug abuse, the amount of contact with birth defects rays, or poison and is in effect; (2) Endometriosis, uterine fibroids, tuberculosis, intrauterine adhesions, endometrial lesions; (3) Polycystic ovary syndrome, ovarian cyst, fallopian tube water; (4) Not conforming to the inclusion criteria, can't take medicine as prescribed, etc.;Exclusion criteria: (1) Uterus does not have function of pregnancy or serious body disease cannot bear, suffering from severe mental disorders, pregnancy infections, sexually transmitted disease, genitourinary system, has the serious bad habits such as drug abuse, the amount of contact with birth defects rays, or poison and is in effect; (2) Endometriosis, uterine fibroids, tuberculosis, intrauterine adhesions, endometrial lesions; (3) Polycystic ovary syndrome, ovarian cyst, fallopian tube water; (4) Not conforming to the inclusion criteria, can't take medicine as prescribed, etc.;Exclusion criteria: (1) Uterus does not have function of pregnancy or serious body disease cannot bear, suffering from severe mental disorders, pregnancy infections, sexually transmitted disease, genitourinary system, has the serious bad habits such as drug abuse, the amount of contact with birth defects rays, or poison and is in effect; (2) Endometriosis, uterine fibroids, tuberculosis, intrauterine adhesions, endometrial lesions; (3) Polycystic ovary syndrome, ovarian cyst, fallopian tube water; (4) Not conforming to the inclusion criteria, can't take medicine as prescribed, etc.;Exclusion criteria: (1) Uterus does not have function of pregnancy or serious body disease cannot bear, suffering from severe mental disorders, pregnancy infections, sexually transmitted disease, genitourinary system, has the serious bad habits such as drug abuse, the amount of contact with birth defects rays, or poison and is in effect; (2) Endometriosis, uterine fibroids, tuberculosis, intrauterine adhesions, endometrial lesions; (3) Polycystic ovary syndrome, ovarian cyst, fallopian tube water; (4) Not conforming to the inclusion criteria, can't take medicine as prescribed, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| advanced oxidation protein products(AOPP);3-nytrotyrosine(3-NT);4-hydroxynonenal(4-HNE);8-hydroxy-2’-deoxyguanosine(8-OHdG);MDA;total antioxidant capacity (T-AOC);superoxide dismutase(SOD);catalase(CAT);glutathione peroxidase(GSH-Px);NQO1;Mitochondrial ultrastructure of granulosa cells;Mitochondrial distribution of granulosa cells;The ATP content of granulosa cells;membrane potential of granulosa cells;MtDNA copy number of granulosa cells; | — |
Countries
China
Contacts
Public ContactHuilan Du;Huilan Du;Huilan Du;Huilan Du;Huilan Du ;;;;
Hebei University of Chinese Medcine;Hebei University of Chinese Medcine;Hebei University of Chinese Medcine;Hebei University of Chinese Medcine;Hebei University of Chinese Medcine
Outcome results
None listed