Adult-Onset Still's Disease
Conditions
Interventions
1:Etoposide
Sponsors
Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai JiaoTong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: AOSD was diagnosed according to the criteria described by Yamaguchi et al; All patients had previously received standard synthetic immunosuppressive drugs and in some cases other biologic agents; Written informed consent form approved for each hospital was requested and obtained from each patient prior to the onset of etoposide treatment.;Inclusion criteria: AOSD was diagnosed according to the criteria described by Yamaguchi et al; All patients had previously received standard synthetic immunosuppressive drugs and in some cases other biologic agents; Written informed consent form approved for each hospital was requested and obtained from each patient prior to the onset of etoposide treatment.;Inclusion criteria: AOSD was diagnosed according to the criteria described by Yamaguchi et al; All patients had previously received standard synthetic immunosuppressive drugs and in some cases other biologic agents; Written informed consent form approved for each hospital was requested and obtained from each patient prior to the onset of etoposide treatment.;Inclusion criteria: AOSD was diagnosed according to the criteria described by Yamaguchi et al; All patients had previously received standard synthetic immunosuppressive drugs and in some cases other biologic agents; Written informed consent form approved for each hospital was requested and obtained from each patient prior to the onset of etoposide treatment.;Inclusion criteria: AOSD was diagnosed according to the criteria described by Yamaguchi et al; All patients had previously received standard synthetic immunosuppressive drugs and in some cases other biologic agents; Written informed consent form approved for each hospital was requested and obtained from each patient prior to the onset of etoposide treatment.
Exclusion criteria
Exclusion criteria: Before the initiation of etoposide treatment, the presence of infections, including hepatitis B or hepatitis C virus infections; MAS was defined following the diagnostic criteria proposed by the updated in 2004 and by Fardet L. et al. were excluded;Exclusion criteria: Before the initiation of etoposide treatment, the presence of infections, including hepatitis B or hepatitis C virus infections; MAS was defined following the diagnostic criteria proposed by the updated in 2004 and by Fardet L. et al. were excluded;Exclusion criteria: Before the initiation of etoposide treatment, the presence of infections, including hepatitis B or hepatitis C virus infections; MAS was defined following the diagnostic criteria proposed by the updated in 2004 and by Fardet L. et al. were excluded;Exclusion criteria: Before the initiation of etoposide treatment, the presence of infections, including hepatitis B or hepatitis C virus infections; MAS was defined following the diagnostic criteria proposed by the updated in 2004 and by Fardet L. et al. were excluded;Exclusion criteria: Before the initiation of etoposide treatment, the presence of infections, including hepatitis B or hepatitis C virus infections; MAS was defined following the diagnostic criteria proposed by the updated in 2004 and by Fardet L. et al. were excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| percentage of patients with the Pouchot score dropped by more than two points; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of laboratory indicators and clinical indicators; | — |
Countries
China
Contacts
Public ContactWang Xiaodong;Wang Xiaodong;Wang Xiaodong;Wang Xiaodong;Wang Xiaodong ;;;;
Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai JiaoTong University;Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai JiaoTong University;Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai JiaoTong University;Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai JiaoTong University;Department of Rheumatology, Renji Hospital South Campus, School of Medicine,
Outcome results
None listed