major craniotomy
Conditions
Interventions
experimental group 1:Traditional strategy of lung protective ventilation
experimental group 2:Lung protective ventilation strategy under optimal peep
Sponsors
The Second Affiliated Hospital of Medical College of Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients and their families signed informed consent; ASA 1-3 grade; over 18 years of age; brain tumors, cerebral aneurysm, cerebral vascular malformation; the operation time more than 3 hours; a BMI of 18 ~ 25kg/m2.
Exclusion criteria
Exclusion criteria: Preoperative radiotherapy in patients with heart failure; ALI/ARDS; or suspected with heart failure; 15 days before operation and received mechanical ventilation (CPAP) treatment; pneumothorax or lung bullae; severe liver and kidney dysfunction; COPD patients who need oxygen therapy or CPAP; postoperative into ICU or postoperative consciousness did not recover; is participating in other clinical intervention trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improved lung infection score;Inflammation factor detection; | — |
Countries
China
Contacts
Public ContactLina Yu
The Second Affiliated Hospital of Medical College of Zhejiang University
Outcome results
None listed