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Effect of hepatectomy combined with postoperative FOLFOX4 for the treatment of hepatocellular carcinoma with portal vein tumor thrombus: A prospective randomised controlled trail

Effect of hepatectomy combined with postoperative FOLFOX4 for the treatment of hepatocellular carcinoma with portal vein tumor thrombus: A prospective randomised controlled trail

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-17012915
Enrollment
Unknown
Registered
2017-10-09
Start date
2017-11-01
Completion date
Unknown
Last updated
2017-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver cancer

Interventions

A:hepatectomy combined with postoperative FOLFOX4

Sponsors

225 Changhai Road, Shanghai, China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged 20 to 70 years old male or non-pregnant female HCC with PVTT patients; 2. Pathologically proved HCC, single tumor <10cm in diameter or multiple lesions confined to one lobe and the PVTT is resectable, without extrahepatic metastasis or adjacent organ involvement before surgery; 3. Liver function is Child-Pugh A; 4. No apparent abnormality of the heart, lung, and kidney; 5. No HCV, HIV and syphilis infection; 6. Patients should sign the informed consent of this study.

Exclusion criteria

Exclusion criteria: 1. If postoperative liver function is Child C, it cannot tolerate radiotherapy; 2. With evidence of extrahepatic metastasis; 3. Severe gastroesophagealvarices with red sign or with variceal hemorrhage before; 4. Malignant or metastatic tumor in other sites in last 5 years; 5. Patients can not be followed-up regularly; 6. Patients participating in other trials or received other treatment previously.

Design outcomes

Primary

MeasureTime frame
DFS;

Countries

China

Contacts

Public ContactCheng Shuqun

Eastern Hepatobiliary Surgical Hospital

chengshuqun163@163.com+86 021-81875251

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026