traumatic brain injury
Conditions
Interventions
group C:According to patients with mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP) conventional liquid therapy.
group CD:Routine liquid therapy at the same time, intravenous infusion of dexmedetomidine 0.5µg / (kg · h) to surgery
group G:Monitoring of SVV by FloTrac / Vigileo to guide intraoperative fluid volume
group GD:Intravenous infusion of dexmedetomidine 1ug / kg 10 minutes before anesthesia induction, followed by intravenous infusion of dexmedetomidine 0.5 µg / (kg · h) to maintain the SVV on a basis o
groupCN:Routine liquid therapy at the same time, complex low dose of norepinephrine (0.01 ~ 0.03µg / (kg · min)) to surgery
group GN:Through FloTrac / Vigileo monitoring of SVV to guide intraoperative fluid volume at the same time, the composite application of norepinephrine 0.01 ~ 0.03µg / (kg · min)
Sponsors
Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients admitted within 24 hours after injury; 2. American society of anesthesiologists classification I to II.Glasgow Coma Score (GCS) score from 6 to 12 points; 3. CT and other imaging data confirmed that patients with cerebral contusion; 4. No other organ damage failure.
Exclusion criteria
Exclusion criteria: 1. Preoperative combined cardiopulmonary disease, cerebral infarction history, liver and kidney dysfunction, cognitive dysfunction, mental history and drug abuse and other patients; 2. Neck vein retrograde puncture site of patients with local infection damage; 3. Combined with intracranial arteriovenous malformations in patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial blood gas analysis(PaO2, SaO2, Hb, BE, lactic acid, blood glucose);Blood gas analysis of internal jugular vein (PjvO2, SjvO2, lactic acid);Serum S-100ß concentration;the average volume of infused crystalloid and colloid solution, the total volume of transfusion, blood loss and urine volume;GOS score;the length of ICU and hospital stay;GCS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters (HR, MAP, SpO2, PETCO2);postoperative pulmonary complications;brain edema; | — |
Countries
China
Contacts
Public ContactZhang Shan
Second Hospital of Hebei Medical University
Outcome results
None listed