bacterial meningitis
Conditions
Interventions
A:Conventional antibiotics treatment until normalization of cerebrospinal-fluid cell profile
B:Sufficient conventional antibiotics treatment until other indeces normalization except cerebrospinal-fluid cell profile
Sponsors
The second affiliated hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Positive cerebrospinal-fluid culture or latex agglutination for H influenzae, S pneumoniae, and N meningitides; 2. More than 20 white blood cells per mL for baby (younger than 1 years old) or 10 for older children (older than 1 years old) of cerebrospinal fluid, with positive blood culture for the same organisms by day 3 of admission; 3. Cerebrospinal-fluid culture and latex agglutination both negative, but more than 100 white blood cells per mL with more than 50% granulocytes and cerebrospinal-fluid glucose less than 50% of blood glucose or less than 1.66 mmol/L; 4. More than 1000 white blood cells per mL of cerebrospinal fluid with 75% polymorphonuclear cells.
Exclusion criteria
Exclusion criteria: Exclusion criteria at enrolment 1. Children bodyweight 3kg or less; 2. Pre-existing neurosurgical conditions; 3. Seizure disorders, cerebral palsy, degenerative neurological disorders; 4. Cranial fractures; 5. Known immunodeficiency states, symptomatic AIDS; 6. Known hypersensitivity to cephalosporins; 7. Cyanotic congenital heart disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of relapse; | — |
Countries
China
Contacts
Public ContactZhongdong Lin
The second affiliated hospital of Wenzhou Medical University
Outcome results
None listed