cervical cancer
Conditions
Interventions
Experimental group:three fractions of brachytherapy before external beam irradiation
Control:Regular radiotherapy
Sponsors
Sun Yat-sen memorial hospital, Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
19 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Patients with newly histologically confirmed squamous-cell carcinoma (according to WHO histological type); 2. Aged 18-70 years; 3. Tumor staged as II/III (according to the FIGO 2009 edition staging system); 4. No evidence of distant metastasis (M0); 5. Performance status KPS > 70; 6. Adequate marrow, normal renal and liver function tese; 7. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. WHO type non-squamous cell carcinoma such as adenocarcinoma, neurosecretory large/small cell carcinoma, and the sarcoma; 2. Prior malignancy (except adequately treated carcinoma in-situ of the cervix or basal/squamous cell carcinoma of the skin); 3. Pregnancy or lactation (consider pregnancy test in women of child-bearing age and emphasize effective contraception during the treatment period); 4. History of previous RT (except for non-melanomatous skin cancers outside intended RT treatment volume); 6. Any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose >1.5×ULN), and emotional disturbance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor complete remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;locoregional failure-free survival; | — |
Contacts
Public ContactShou-min Bai
Sun Yat-sen memorial hospital, Sun Yat-sen University
Outcome results
None listed