Chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome
Conditions
Interventions
BiPAP S/T group:BiPAP S/T
BiPAP AVAPS-AE group:BiPAP AVAPS-AE
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science & Technology
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Stage I 1. All hospitalized patients who meet the COPD diagnostic creteria; 2. Less than 24 hours after admission; 3. Agree to paticipant in this study. Stage II: 1. To be diagnosed with Overlap syndrome and AHI=15/h; 2. To be diagnosed with COPD by Pulmonary Function Tests within half a year; 3. Need NPPV treatment regarding to clinical judgements (Conscious,RR>25/min,7.2545mmHg); 4. Strong airway protection ability; 5. Without head and facial imjuries; 6. Only adults>30kg. Stage III: 1. Hospitalized due to AECOPD; 2. PH=7.35, PaCO2>45mmHg during admission (Quiescent condition, Air); 3. PH>7.35, PaCO2>45mmHg when discharged(Quiescent condition, Air); 4. Treated with NPPV during hospitalization with good compliance; 5. BMI30kg.
Exclusion criteria
Exclusion criteria: Stage I: 1. Patient who refuse to participate in this study. Stage II: 1. Type II respiratory faliure that is caused by COPD; 2. Complicated with pulmonary disease but COPD; 3. BMI>35kg/m2; 4. Infectious diseases(such as Pulmonary Tuberculosis,etc); 5. Quit during study; 6. Death during study. Stage III: 1. Type II respirotery failure that is not caused by COPD; 2. Complicated with pulmonaty diseases but COPD; 3. Poor compliance duting hospital NPPV treatment; 4. Infectious diseases(such as Pulmonary Tuberculosis,etc); 5. Need long-term Glucocorticoid therapy(not including inhealed corticosteroids); 6. Co-morbid with other complication and Predictive survival timme is less than 1 year; 7. Already under home BiPAP treatment; 8. Quit during study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSQI;Pulmonary function test;AHI;blood gas analysis;NPPV treatment duration when in hospital;SACS; | — |
Secondary
| Measure | Time frame |
|---|---|
| mMRC;CAT;mEpworth;Acute exacerbation COPD of the interval and duration; | — |
Countries
China
Contacts
Public ContactJinnong Zhang
Union Hospital, Tongji Medical College, Huazhong University of Science & Technology
Outcome results
None listed