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The application and basic research of target CPP management in severe traumatic brain injury

The application and basic research of target CPP management in severe traumatic brain injury

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-INR-17012612
Enrollment
Unknown
Registered
2017-09-07
Start date
2018-01-01
Completion date
Unknown
Last updated
2017-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe traumtic brain injury

Interventions

Routine operation group:MAP 80-90mmHg
Target CPP Management Group:MAP 60-70mmHg

Sponsors

The 101st Hospital of PLA
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18-65 years old, male or female non pregnant, the first cranial CT scan showed cerebral contusion, GCS4-8 after admission or after resuscitation, the initial intracranial pressure is larger than 25mmHg, and need for craniotomy. Signed informed consent.

Exclusion criteria

Exclusion criteria: GCS 3, bilateral pupil dilation fixed, no spontaneous breathing, unstable vital signs, MAP<60mmHg or SPO2 is less than or equal to 94% after recovery. Severe combined injury or main injury site is not in the brain. Non informed consent. Pregnant women

Design outcomes

Primary

MeasureTime frame
Intraoperative encephalocele;The GOS score of 6 months after operation;NDRG2;—

Secondary

MeasureTime frame
Delayed bleeding;—

Countries

China

Contacts

Public ContactChen Weiliang

The 101st Hospital of PLA

497425408@qq.com+86 15505281937

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026