Melasma/Chloasma
Conditions
Interventions
Experiment group:A new whitening formula
Control group:Arbutin whitening formula
Placebo group:Placebo
Sponsors
The First Hospital Affiliated of Kunming Medical University
Eligibility
Sex/Gender
All
Age
25 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. At the age of 25-55 years old, male or female, without a clear system of organic disease; 2. Meet the diagnostic criteria of melasma; 3. Patients are willing to use SPF>30 sunscreen during the entire study period without direct exposure to the sun; 4. Patients did not use any other freckle or whitening products or received other treatments (drugs, chemical stripping, laser, etc.) in the first 1 months; 5. During the whole study period, no other freckle removing, whitening products and other treatments (drugs, lasers, etc.) were used; 6. Patients have signed the informed consent and are willing to complete the study.
Exclusion criteria
Exclusion criteria: 1. Patients have serious heart, kidney, liver, endocrine system disease or the patient that has tumor and immune deficient disease; 2. Pregnant or lactating women; 3. Patients have used other freckle, whitening products, or accepted other treatment methods (such as: drugs, chemical stripping, laser, etc.)for 1 month before studyl; 4. Does not meet the diagnostic criteria of melasma; 5. Patients suffering from herpes simplex, sensitive skin, or have broken, impregnated, erosion and other skin lesions; 6. Known to be allergic to the subject; 7. Can not guarantee not to use other freckle, whitening products, and accept other treatment methods (such as: drugs, lasers, etc.) throughout the study period; 8. Staff directly involved in the study; 9. Patients currently participating in other clinical studies or have participated in other clinical studies within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melasma area severity index(MASI);Lab (CM-2600d, Minolta, Japan);VISIA(VISIA-CR, Canfield, USA).;Skin physiology function test(MX 18;Courage &Khazaka, Germany);Physicians Global Assessment (PGA);Subjects Assessment;Dermoscopy;Confocal scanning laser microscopy (CSLM); | — |
Countries
China
Contacts
Public ContactLi He
The First Hospital Affiliated of Kunming Medical University
Outcome results
None listed