idiopathic membranous nephropathy
Conditions
Interventions
1:Cyclosporine
2:cyclosporine combined with sirolimus
Sponsors
Renal Division, Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-70 years; 2. diagnosed as idiopathic membranous nephropathy by renal biopsy; 3. corticosteroids and immunosuppressive agents were not received in the recent 3 months; 4. blood pressure <140/90mmHg; 5. proteinuria =3.5g/day and eGFR= 45ml/min /1.73m2, with at least 3-month treatment of maximum tolerance dasage of ACEI/ARB; 6. serum creatinie =133umol/L; 7. agree to sign informed consent
Exclusion criteria
Exclusion criteria: 1. any type of secondary membranous nephropathy by renal biopsy; 2. any other tyoe of kidney disease; 3. uncontrolled infection; 4. Interstitial pneumonia; 5. new onset of cadiovascular disease in recent 3 months; 6. severe liver disease, liver enzyme elevation is not higher than 3 times; 7. uncontrolled severe hypertension; 8. A new or recurring malignancy within 8.5 years; 9. peptic ulcer or active digestive tract bleeding; 10. severe autoimmune disease; 11. pregnancy, lactation or scheduled pregnancy; 12. expected survival was less than December; 13. other clinical studies are currently in progress; 14. do not agree to sign informed consent; 15. the researchers found other conditions unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proteinuria; | — |
Countries
China
Contacts
Public ContactMinghui Zhao
Renal Division, Peking University First Hospital
Outcome results
None listed