Radioiodme-refractory Differentiated Thyroid Cancer
Conditions
Interventions
Experience group:Iodine 125 particle implantation therapy
Experience group:Take pills of Euthyrox
control group:Take pills of Euthyrox
Sponsors
Shanghai Tenth Peaple's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) in accordance with the "2015 American Thyroid Association (ATA) adult thyroid nodules and differentiated thyroid cancer management guidelines" clearly defined RR-DTC; (2) pathologically confirmed metastatic or recurrent DTC; with measurable or evaluable lesions; (3) aged 18-90 years; (4) inoperable patients; (5) the expected survival time was >3 months; (6) blood neutrophil absolute value is more than 1.5 x 10^9/L = 70 * 10^9/L, platelet, hemoglobin 90g/L; coagulation function: <15s prothrombin time, activated partial thromboplastin time <50s; renal function, creatinine and urea nitrogen in normal liver function: transaminase; not more than 3 times higher than normal limit; normal ECG; KPS score more than 60 points; active infection; (7) agree with the accepted radioactive particles implantation therapy, and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) unable to maintain a steady position and can not cooperate with the implantation of 125I particles; (2) patients during pregnancy; (3) recurrent and metastatic lesions were present in patients with acute infection; (4) patients with coagulopathy can not be corrected by treatment; (5) incomplete data, unable to complete statistics and analysis; (6) informed and disconsent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metastasis or recurrence of tumor size;number of metastasis or recurrence tumor lesions;Serum thyroglobulin; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine examination;Serum aspartate aminotransferase;Glutamic pyruvic transaminase;serum creatinine;Routine thyroid function five items (blood, T3, T4, fT3, fT4, TSH);electrocardiogram;KPS score; | — |
Countries
China
Contacts
Public ContactZhongwei LV
Shanghai Tenth Peaple's Hospital
Outcome results
None listed