Sepsis
Conditions
Interventions
Group 1:Regular fluid therapy
Group 2:Restricted fluid resuscitation group
Sponsors
Ruijin Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. sepsis patients in accordance with the Sepsis 3.0 definition 1) Confirm or suspect the presence of focal infection; 2) SOFA increase =1 compared to the baseline due to infection); 3) the first blood lactate in our hospital is = 2mmol/L or MAP<65mmHg(or SBP<90) after 20ml/kg fluid bolus; or vasoactive drugs were required to maintain MAP greater than or equal to 65mmHg; 2. Aged 18-85 years; 3. Sign informed consent form.
Exclusion criteria
Exclusion criteria: 1. pregnancy, preparing for pregnancy or breastfeeding ; 2. with co-morbidity such as AE-COPD, stroke, lung edema, acute coronary syndrome; 3. with contra-indication of CVC (central venous catheter) placement; 4. Active gastrointestinal bleeding; 5. seizure; 6. poisoning; 7. trauma, major burn; 8. uncured malignant tumor; 9. emergency operation; 10. systemic autoimmune disease or immunosuppression (solid organ or bone marrow transplantation, AIDS, long-term use of immunosuppressive agents or hormones); 11. have a desire to cease or desist from maintaining life in a human manner (treatment abandoning); 12. an estimated survival time of <28 days for the underlying disease or terminal state; 13. death within 24 hours; 14. cardiopulmonary resuscitation was performed within 72 hours and nerve function was not restored; 15. the source of infection cannot be removed, such as surgical intervention or drainage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mortality in 28 days; | — |
Countries
China
Contacts
Public ContactErzhen Chen
Ruijin Hospital
Outcome results
None listed