unexplained recurrent pregnancy loss
Conditions
Interventions
PGS group:IVF/ICSI+PGS 2.0
Control group:IVF/ICSI
Sponsors
Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital, Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 48 Years
Inclusion criteria
Inclusion criteria: 1. regular menstrual cycles and normal level of E2, P, FSH, LH, T,RPL in the early follicular phase; 2. BMI 18.50-24.90 3. no history of poison contact; 4. normal uterine and adnexal ultrasonography; 5. TORCH(-), chlamydia(-), mycoplasma(-), normal leucorrhoea routine, anti-phospholipid antibody (-), antinuclear antibody(-); 6. for the couple, no blood type incompatibility or ABO antibody IgG=164 and normal blood chromosome analysis
Exclusion criteria
Exclusion criteria: 1. hydrosalpinx without operation; endometriosis; polycystic ovary syndrome; adenomyosis; uterine leiomyomata(submucous myoma or non-submucous myoma which size was exceed 4cm and/or with the compressed endometrium);uterine cavity lesions(such as uterine malformation, intrauterine adhesions, the septate uterus, endometritis etc); 2. the former abortion is because of luteal phase defect without treatment; 3. FSH=12IU/L or AMH=1.2ng/ml; 4. thyroid dysfunction or increased CA125 level; 5. acute inflammation of genitourinary system or STD carriers; 6. unable to comply with the study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Embryo implantation;Clinical pregnancy;Time to pregnancy; | — |
Countries
China
Contacts
Public ContactSUN XIAOXI
ShangHai Ji Ai Genetics & IVF Institute
Outcome results
None listed