Hip osteoarthritis
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Primary unilateral total hip artropasty; (2) Normal platelet and coagulation function preoperatively; (3) Normal intravenous ultrasound in the lower extremities preoperatively; (4) To be able to and willing to provide signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Systemic infections such as pulmonary infection or urinary tract infection are not controlled preoperatively; (2) Abnormal immune function or combined immune-related disease preoperatively; (3) Abnormal inflammatory index preoperatively (C-reactive protein >20 mg/L); (4) Abnormal fibrinolysis index preoperatively (FDP > 5mg/L); (5) Discontinuation of oral anticoagulants or aspirin less than 1 week; (6) Allergy to tranexamic acid (TXA) or dexamethasone or have contraindications; (7) Patients at high risk of thrombosis; (8) History of deep vein thrombosis (VTE, calf muscle vein thrombosis or superficial vein thrombosis, pulmonary embolism); (9) serious liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PT, APTT, FDP, D-DIMER;total blood loss;Hb drop;inflammatory index(CRP, IL-1ß, IL-6, TNF-a);transfusion;VAS pain score;opioid consumption;hip circumference;Range of motion;postoperative hospital stay;HSS;HOOS; | — |
Contacts
Public ContactZhou Zongke
West China Hospital, Sichuan University
Outcome results
None listed